One strike loading organ culture model to investigate the post-traumatic disc degenerative condition
نویسندگان
چکیده
منابع مشابه
An organ culture system to model early degenerative changes of the intervertebral disc
INTRODUCTION Back pain, a significant source of morbidity in our society, is related to the degenerative changes of the intervertebral disc. At present, the treatment of disc disease consists of therapies that are aimed at symptomatic relief. This shortcoming stems in large part from our lack of understanding of the biochemical and molecular events that drive the disease process. The goal of th...
متن کاملAn organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes
INTRODUCTION Despite many advances in our understanding of the molecular basis of disc degeneration, there remains a paucity of preclinical models which can be used to study the biochemical and molecular events that drive disc degeneration, and the effects of potential therapeutic interventions. The goal of this study is to characterize global gene expression changes in a disc organ culture sys...
متن کاملCorrection: Loading-Induced Heat-Shock Response in Bovine Intervertebral Disc Organ Culture
[This corrects the article DOI: 10.1371/journal.pone.0161615.].
متن کاملLoading-Induced Heat-Shock Response in Bovine Intervertebral Disc Organ Culture
Mechanical loading has been shown to affect cell viability and matrix maintenance in the intervertebral disc (IVD) but there is no investigation on how cells survive mechanical stress and whether the IVD cells perceive mechanical loading as stress and respond by expression of heat shock proteins. This study investigates the stress response in the IVD in response to compressive loading. Bovine c...
متن کاملDevelopment of a whole disc organ culture system to study human intervertebral disc
STUDY TYPE Basic science Objective: Low back pain is one of the most common health problems1 and is strongly associated with intervertebral disc degeneration, (IVD). Current treatments remove the symptoms without reversing or even retarding the underlying problem. Development of new therapy for the regeneration of the degenerative IVD is complicated by the lack of a validated long-term organ ...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Translation
سال: 2021
ISSN: 2214-031X
DOI: 10.1016/j.jot.2020.08.003